In-vitro Anti-Inflammatory and Anticancer activities of Octoblepharum albidum Hedw.

  • Kishore Naidu K A.U. College of Pharmaceutical Sciences, Andhra University, Visakhapatnam-530003, India
    vinaybharadwajtatipamula@duytan.edu.vn
  • Satya Sowbhagya Priya A A.U. College of Pharmaceutical Sciences, Andhra University, Visakhapatnam-530003, India
  • Vinay Bharadwaj T Institute of Research and Development, Duy Tan University, Da Nang-550000, Vietnam

Abstract

The chemical investigation of ethyl acetate extract of stressed moss Octoblepharum albidum Hedw. (EA) yielded two known metabolites, namely daucosterol (1) and friedelin (2), which are characterized by using elemental and spectral analysis, also these metabolites are for the first conveyed from this species. EA and its secondary metabolites (1-2) were screened for in vitro anti-inflammatory (protein denaturation method), and anticancer (SRB assay using Ovary (PA1), Cervical (C-33A), and Lung (NCI-H358) cancer cell lines). The outcomes of bioassays displayed that 1 and 2 have effective inhibitory outlines against bovine albumin protein denaturation with a 50% inhibitory values of 435 and 403 µg/mL, respectively. Furthermore, compounds 1 and 2 demonstrated a noteworthy degree of specificity against PA1, C-33A, and NCI-H358, also they revealed a low degree of specificity against normal (NHME) cell line states non-lethal to normal human cells. The present study is the first report on the chemical examination of moss O. albidum.Octoblepharum albidum

Keywords: Octoblepharum albidum, Moss, Protein Denaturation, Anti-inflammatory, Anti-cancer, Acute toxicity studies

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Naidu K K, Priya A SS, Bharadwaj T V. In-vitro Anti-Inflammatory and Anticancer activities of Octoblepharum albidum Hedw. Am J Med Nat Sci [Internet]. 2020Jul.27 [cited 2025Sep.19];1(1):19-4. Available from: https://www.ajmns.com/index.php/journal/article/view/5
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Vol. 1 No. 1 (2020): Vol 1 Issue 1 April, 2020
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