Design And Fabrication of Microneedle For Controlled Drug Release

Abstract

Microneedle (MN) technology has emerged as a minimally invasive and effective substitute for conventional injectable and oral drug delivery systems. Although the approach has been widely explored, its clinical translation remains restricted because of limitations such as insufficient drug-loading capacity and challenges in achieving optimal therapeutic levels. Dissolvable and biodegradable microneedles are primarily applicable for low-dose treatments, including immunization and delivery of Highly potent medications.Microneedles provide a novel strategy for transdermal drug administration by overcoming the protective barrier of the epidermis. These micro-sized projections create temporary channels within the skin, thereby reducing barrier resistance and enhancing drug permeation. The technology has gained considerable interest in biomedical research due to its capability to deliver various therapeutic agents, including biological molecules, vaccines, pharmaceuticals, and other medicinal compounds, through the skin. Microneedle systems have demonstrated applications in vaccine delivery, systemic therapy, and cosmetic treatment. Continuous advancements in this technology highlight its potential to improve therapeutic effectiveness and patient adherence through safe and efficient transdermal drug delivery.