POLYMER BASED GASTRO RETENTIVE DRUG DELIVERY SYSTEMS FOR SUSTAINED AND SITE SPECIFIC ACTION
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Vetti Divyanjali
Priyadarshini Institute of Pharmaceutical Education and Research, 5TH Mile, Pulladigunta, Guntur-522017, Andhra Pradesh, India.
divyanjalidivya70@gmail.com
Abstract
Gastro-retentive drug delivery systems (GRDDS) have emerged as an important new area of research in the field of oral pharmaceuticals, where the goal is to increase the therapeutic effect of a drug by extending the time it spends in the stomach, thereby improving its bioavailability . Current trends in GRDDSs involve the continual updating and expanding of the various types of GRDDS architecture, which include some higher-level floating GRDDS, mucoadhesive and bioadhesive formulations, expandable and swelling matrices, and superporous hydrogels. This is being done to provide for optimal retention and controlled release of these forms of drugs within the stomach. New polymer technologies, particularly biodegradable and other natural polymers, continue to be researched to improve the biocompatibility, while at the same time addressing the issues associated with safety and regulations surrounding their use. Also, the use of nanotechnology is becoming increasingly common within GRDDS systems, as both nanoparticle-based carriers and microspheres provide superior targeting accuracy, stability, and mucosal interaction. These developments are making GRDDS a more effective, patient-centric oral drug delivery system with significant clinical benefits.
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