HERBAL BASED INTERVENTIONS IN CANCER THERAPY

  • Thippireddy Ashok Priyadarshini Institute of Pharmaceutical Education and Research, 5TH Mile, Pulladigunta, Guntur-522017, Andhra Pradesh, India.
    ashokt9624@gmail.com

Abstract

Cancer is complex and multifactorial disease that continues to be a major health concern worldwide. In spite of significant advances in conventional cancer curatives, there is a growing interest in exploring volition and complementary approaches to cancer treatment. Herbal natural products have been used for centuries in traditional drug to prevent and treat various conditions, including cancer. This review highlights the eventuality of herbal natural products as anti-cancer agents, focusing on their bioactive composites. This review explores the use of various parts of herbal medicinal plants and their active phytoconstituents in the prevention and treatment of various types of cancer. A comprehensive survey of literature was conducted using the multiple databases to identify anticancer medicinal plants and their uses. Identified herbs exhibit therapeutic effects via mechanisms such as inhibition of cancer-promoting enzymes and hormones, activation of DNA form processes, reduction of free radical revolutionary conformation, and Improvement of the immune system. Medicinal plants are majorly contributed to inhibiting the progression of cancer. Herbal anti-cancer medicines offer therapeutic advantages, particularly selective toxicity against cancer cells, reducing the adverse side effects associated with conventional chemotherapy. Multiple studies and clinical trials are investigating their efficacity, safety and mechanisms of action on different of cancers such as lung, prostate and, breast carcinoma.

Keywords: Cancer, medicinal plants, herbal drugs, therapy, phytoconstituent

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References

1. He L, Gu J, Lim LY, Yuan ZX, Mo J. Nanomedicine-mediated therapies to target breast cancer stem cells. Front Pharmacol. 2016;7:313. doi:10.3389/fphar.2016.00313.
2. Kiranmai M, Renuka P, Brahmaiah B, Chandu BR. Vitamin D as a promising anticancer agent. Int J Res Pharm Chem. Available from: https://www.ijrpc.com/files/12-2108.pdf
3. Huang B, Zhang Y. Teaching an old dog new tricks: Drug discovery by repositioning natural products and their derivatives. Drug Discov Today. 2022;27(7):1936-1944. doi:10.1016/j.drudis.2022.02.007.
4. Nandipati MC, Sumalatha G, Baburao C, Babu JR, Sridevi C. Antitumor activity of Mimosa rubicaulis Lam. against Ehrlich ascites carcinoma in Swiss albino mice. Int J Pharm Sci Res. 2014;5(4):1514.
5. Rani TT, Brahmaiah B, Revathi B, Nama S, Baburao C. Targeting of anti-cancer drugs through nanoparticles. World J Pharm Pharm Sci. 2017. doi:10.20959/WJPPS20177-9441.
6. Singh A, Jha SK, Dwivedi PC, Srivastava U, Pal A. Revolutionizing healthcare: Integrating electronics, AI, traditional, and conventional methods. World J Adv Res Rev. 2024;23:2426-2434. doi:10.30574/wjarr.2024.23.3.2919.
7. Shamim, Ali S, Ali T, Sharma H, Kishor BN, Jha SK. Recent advances in monodisperse gold nanoparticle delivery, synthesis, and emerging applications in cancer therapy. Plasmonics. 2025;20(9):7121-7141.
8. Patel S, Singh S, Gupta AK, Dalimbe AY, Muthoju SM, Pawar AR, Jha SK, Gupta AJ. Ayurveda and common Indian spices: A natural alternative for cancer therapy. Ayush J Integr Oncol. 2025;2(2):91-102. doi:10.4103/ajio.ajio_20_25.
9. Savoca MR, Arcury TA, Leng X, Chen H, Bell RA, Anderson AM, Kohrman T, Frazier RJ, Gilbert GH, Quandt SA. Severe tooth loss in older adults as a key indicator of compromised dietary quality. Public Health Nutr. 2010;13(4):466-474. doi:10.1017/S1368980009991236.
10. Kirtonia A, Sethi G, Garg M. The multifaceted role of reactive oxygen species in tumorigenesis. Cell Mol Life Sci. 2020;77(22):4459-4483. doi:10.1007/s00018-020-03536-5.
11. Singh NK, Sengar AS, Jha SK. A review of Ayurvedic measures for preventing COVID-19 and promoting health during pregnancy. J Indian Syst Med. 2024;12(2):61-65. doi:10.4103/jism.jism_81_23.
12. Lamson DW, Brignall MS. Antioxidants in cancer therapy: Their actions and interactions with oncologic therapies. Altern Med Rev. 1999;4(5):304-329.
13. World Health Organization. WHO guidelines on safety monitoring of herbal medicines in pharmacovigilance systems. Geneva: World Health Organization; 2004.
14. Han Y, Wang H, Xu W, Cao B, Han L, Jia L, Xu Y, Zhang Q, Wang X, Zhang G, et al. Chinese herbal medicine as maintenance therapy for improving the quality of life for advanced non-small cell lung cancer patients. Complement Ther Med. 2016;24:81-89. doi:10.1016/j.ctim.2015.12.008.
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1.
Thippireddy A. HERBAL BASED INTERVENTIONS IN CANCER THERAPY. Am J Med Nat Sci [Internet]. 2026Jun.20 [cited 2026Jun.21];7(2):1-. Available from: https://www.ajmns.com/index.php/journal/article/view/33
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Review Articles