FORMULATION AND IN VITRO CHARACTERIZATION OF AMLODIPINE-LOADED CHITOSAN NANOPARTICLES EMBEDDED IN CARBOPOL GEL FOR TRANSDERMAL DELIVERY
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Audinarayana Nelavala
Associate Professor, Department of Pharmaceutics, Sri Venkateswara College of Pharmacy (Autonomous), RVS Nagar, Chittoor – 517127.
audinarayana@svcop.in
Abstract
The present work showed that transdermal delivery system for Amlodipine based on chitosan nanoparticles dispersed into gel was successfully prepared and characterized. There is no Incompatability between drug and polymers by performing FTIR and DSC. To characterize the rate controlling membrane of transdermal patchs. The thickness ranged between TNPGF1 to F9 0.11 ± 0.05 mm to 0.19 ± 0.07 mm, which indicates that they are uniform in thickness. The different batches of formulations weights variations were relatively good uniformity of weight variations among the various batches was observed, with all formulations and ranged from 1.40 ± 1.2% to 1.78 ± 2.0%. The flatness study showed that all the formulations had the same strip length before and after their cuts, indicating 99% flatness. The Tensile strength of the TNPGF1 to TNPGF9 shows the 10.14 ± 1.19 to 12.78 ± 2.45 shows the excellent viscosity. The total amount of drug is present in the transdermal patchs of TNPGF1 to TNPGF9 was found to be 90.5 ± 0.3 % to 98.5 ± 0.1 %. In-vitro Franz’s diffusion drug Release Studies among all formulations the best formulation was TNPGF6. The drug release through the transdermal patches of Amlodipine follows First order kinetics with diffusion controlled mechanism. Effect of penetration enhancer like dimethyl sulfoxide has been checked on in-vitro permeation of drug and was found to be effective. Gels may create a drug reservoir to provide the system with Amlodipine over long period of time to control the blood pressure.
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